OR, are these metal nano particles defined in this
new patent application, helping to create PrPSc??
Interesting that these metal nano particles used in
this patent application are magnetic.
Dr Supattapone will be speaking at the Prion 2013
meeting at the Banff Springs hotel May 26 - 29.
Premier Redford and her DP are speaking at the
welcome reception on the 26th. Can't expect
these two to miss out on a free stay at this
beautiful hotel. I don't expect much talk about the
metal prion connection, it implies toxicity as
opposed to infection.
Section (0013) gives the reader the distinct
impression that the applicants are leaving open
the method of disease progression, giving their
own definition of an "infectious prion":
Quote - "0013] PrP.sup.C is known in the art as
the naturally expressed glycoprotein PrP.sup.C,
also known as PrP-sen, which is found in the
neurons of mammals. Not to be held to any
particular mechanism of action, it is believed that
contact between PrP.sup.C and an infectious
prion or PrP.sup.Sc brings about a conformational
change in PrP.sup.C, converting it from a protein
primarily composed of alpha-helices to a protein
primarily composed of beta-sheets. This
conversion creates a protease resistant, prion
protein (i.e., PrP.sup.Sc, PrP-res) associated with
prion disease. Therefore, the term "infectious
prion protein" is intended to mean a prion protein
which is protease resistant and causes a prion-
associated disease. "
United States Patent Application 20130085263
Kind Code A1
Supattapone; Surachai ; et al. April 4, 2013
METHOD FOR NON-COVALENT
IMMOBILIZATION OF INFECTIOUS PRION
PROTEIN
Abstract
The present invention is method for non-
covalently immobilizing an infectious prion protein
using a magnetic substrate.
Inventors: Supattapone; Surachai; (Hanover, NH) ;
Miller; Michael B.; (Hanover, NH)
Applicant:
Name City State Country
Supattapone; Surachai
Miller; Michael B.
Hanover
Hanover
NH
NH
US
US
new patent application, helping to create PrPSc??
Interesting that these metal nano particles used in
this patent application are magnetic.
Dr Supattapone will be speaking at the Prion 2013
meeting at the Banff Springs hotel May 26 - 29.
Premier Redford and her DP are speaking at the
welcome reception on the 26th. Can't expect
these two to miss out on a free stay at this
beautiful hotel. I don't expect much talk about the
metal prion connection, it implies toxicity as
opposed to infection.
Section (0013) gives the reader the distinct
impression that the applicants are leaving open
the method of disease progression, giving their
own definition of an "infectious prion":
Quote - "0013] PrP.sup.C is known in the art as
the naturally expressed glycoprotein PrP.sup.C,
also known as PrP-sen, which is found in the
neurons of mammals. Not to be held to any
particular mechanism of action, it is believed that
contact between PrP.sup.C and an infectious
prion or PrP.sup.Sc brings about a conformational
change in PrP.sup.C, converting it from a protein
primarily composed of alpha-helices to a protein
primarily composed of beta-sheets. This
conversion creates a protease resistant, prion
protein (i.e., PrP.sup.Sc, PrP-res) associated with
prion disease. Therefore, the term "infectious
prion protein" is intended to mean a prion protein
which is protease resistant and causes a prion-
associated disease. "
United States Patent Application 20130085263
Kind Code A1
Supattapone; Surachai ; et al. April 4, 2013
METHOD FOR NON-COVALENT
IMMOBILIZATION OF INFECTIOUS PRION
PROTEIN
Abstract
The present invention is method for non-
covalently immobilizing an infectious prion protein
using a magnetic substrate.
Inventors: Supattapone; Surachai; (Hanover, NH) ;
Miller; Michael B.; (Hanover, NH)
Applicant:
Name City State Country
Supattapone; Surachai
Miller; Michael B.
Hanover
Hanover
NH
NH
US
US