Flu

[malleefarmer]

Guess you guys have same tests going on, but a lab in Sydney has found ivermectin is killing cv19 in 48 hours, not sure about method used but far out a sheep and cattle parasite control may be part of solution who would have thought.

Dunno how long the testing etc will take might be to risky who knows. And not fake news.

[wd9]

Guess you guys have same tests going on, but a lab in Sydney has found ivermectin is killing cv19 in 48 hours, not sure about method used but far out a sheep and cattle parasite control may be part of solution who would have thought.

Dunno how long the testing etc will take might be to risky who knows. And not fake news.

In vitro or in vivo?

[malleefarmer]

An anti-parasitic drug available throughout the world has been found to kill COVID-19 within 48 hours. A Monash University-led study has shown a single dose of the drug Ivermectin could stop the SARS-CoV-2 virus growing in cell culture. #coronavirus

Did a bit more research cultured cells and application just pasted on I believe

And even a bit more research think a few countries are fiddling with it presume Canada as well, I’m sure they all talk shop the immunologists

[Guest]

Guess you guys have same tests going on, but a lab in Sydney has found ivermectin is killing cv19 in 48 hours, not sure about method used but far out a sheep and cattle parasite control may be part of solution who would have thought.

Dunno how long the testing etc will take might be to risky who knows. And not fake news.

Usta use it in pigs all the time
One shot and worms out next day

[LEP]

Usta use it in pigs all the time
One shot and worms out next day

Could drop a shot at Rideau cottage. Got a worm there I would like to get rid of.

[malleefarmer]

Usta use it in pigs all the time
One shot and worms out next day

Yeah it’s good for worms but a virus will keep open mind.

[TOM4CWB]

malleefarmer; An anti-parasitic drug available throughout the world has been found to kill COVID-19 within 48 hours. A Monash University-led study has shown a single dose of the drug Ivermectin could stop the SARS-CoV-2 virus growing in cell culture. #coronavirus



Mallee apparently Ivermectin is used on humans all the time:

"Ivermectin Dosage
Medically reviewed by Drugs.com. Last updated on Jan 3, 2020.

OverviewSide EffectsDosageProfessionalInteractionsMore
Applies to the following strengths: 3 mg; 6 mg

Usual Adult Dose for:
Onchocerciasis
Strongyloidiasis
Ascariasis
Cutaneous Larva Migrans
Filariasis
Scabies
Usual Pediatric Dose for:
Filariasis
Additional dosage information:

Renal Dose Adjustments
Liver Dose Adjustments
Dose Adjustments
Precautions
Dialysis
Other Comments
Usual Adult Dose for Onchocerciasis
0.15 mg/kg orally once every 12 months
Patients with heavy ocular infection may require retreatment every 6 months. Retreatment may be considered at intervals as short as 3 months.

Dosage guidelines based on body weight:
15 to 25 kg: 3 mg orally one time
26 to 44 kg: 6 mg orally one time
45 to 64 kg: 9 mg orally one time
65 to 84 kg: 12 mg orally one time
85 kg or more: 0.15 mg/kg orally one time

Usual Adult Dose for Strongyloidiasis
0.2 mg/kg orally once
In immunocompromised (including HIV) patients, the treatment of strongyloidiasis may be refractory requiring repeated treatment (i.e., every 2 weeks) and suppressive therapy (i.e., once a month), although well-controlled studies are not available. Cure may not be achievable in these patients.

Dosage guidelines based on body weight:
15 to 24 kg: 3 mg orally one time
25 to 35 kg: 6 mg orally one time
36 to 50 kg: 9 mg orally one time
51 to 65 kg: 12 mg orally one time
66 to 79 kg: 15 mg orally one time
80 kg or more: 0.2 mg/kg orally one time

Usual Adult Dose for Ascariasis
0.2 mg/kg orally once...

https://www.drugs.com/dosage/ivermectin.html

Drug Companies would never go for this... just like cheap malaria drugs...

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Mass treatment with ivermectin: an underutilized public health strategy

Rick Speare (1) & David Durrheim (1)
Ivermectin was a revolutionary drug in the 1980s, the forerunner of a new group of antiparasitic agents with activity against both parasitic nematodes and arthropods. Initially it was marketed for veterinary use by Merck & Co. Inc.; it was used largely for nematode control in cattle, horses, pigs and dogs and became the standard for control of the ectoparasitic disease, scabies. The injectable cattle formulation, Ivomec, became the world’s most profitable veterinary drug (1).

Merck recognized Ivermectin’s potential for human use, particularly in the control of filariasis and most notably onchocerciasis, the cause of river blindness in West Africa, in the early 1980s. In collaboration with WHO, nongovernmental organizations and affected national governments, the company initiated a drug donation programme for onchocerciasis control that subsequently became the global model for philanthropic partnerships between pharmaceutical companies and countries unable to afford the drug. Profits from the veterinary use of ivermectin supported this programme (1).

Merck’s patent on ivermectin expired in 1996, though it was extended for different periods in various countries. Thus, other companies’ ivermectin preparations are now commercially available. Bioavailability of drugs depends on formulation and manufacturing processes, so the results obtained with the ivermectin manufactured by Merck may not apply to the new products. It is thus encouraging to see clinical trials evaluating new formulations of this valuable drug.

Heukelbach et al. (pp.563–579) report a study that investigates changes in parasitological parameters and the occurrence of side-effects after treatment with ivermectin in a Brazilian community heavily parasitized with intestinal helminths and ectoparasites. The trial was unblinded and uncontrolled, but provided valuable information. Community members, ineligible for ivermectin, were treated with mebendazole, albendazole or deltamethrin to achieve a high level of coverage. Of particular importance was the finding that ivermectin was highly effective against Strongyloides stercoralis, with a 94% reduction in prevalence that was sustained for nine months. This provided field evidence for a paper that predicted that strongyloidiasis in heavily endemic communities could be successfully controlled with a highly effective drug, owing to its low transmission potential (2). The evidence presented by Heukelbach et al. adds considerably to evidence from smaller-scale controlled trials (3–6).

Ivermectin has valuable public health applications for controlling strongyloidiasis and scabies (by breaking the infection cycle through its the****utic effect) and filariasis, through its effect on transmission. Ivermectin also acts against other intestinal nematodes, but it is not the most effective drug available. In control programmes for filariasis, ivermectin is the drug of choice in areas with onchocerciasis, but can be replaced by diethylcarbamazine for control of other filarial diseases.

Since ivermectin’s use in the human field, adverse reactions occurred in 50% or more of the population (7) and ivermectin was “tainted” with a high adverse reaction profile, despite evidence that the majority of such reactions were attributable to the interaction between the drug and the disease, not to the drug itself (8). A number of follow-up studies have found that inadvertent filariasis mass campaign use of ivermectin during pregnancy has not been associated with adverse pregnancy outcomes or negative effects on pregnant women or their offspring (9). The lack of serious adverse events found in the study reported by Heukelbach et al. is reassuring, as the low incidence of minor adverse events fell from 14% after the initial treatment to 5% 10 days later.

[newguy]

I assume you are referring to the injectable and not the pour on.When our cats get ear mites 2 drops in each ear and they are gone.

[TOM4CWB]

I assume you are referring to the injectable and not the pour on.When our cats get ear mites 2 drops in each ear and they are gone.

"Australian Scientists have shown that an anti-parasitic drug already available around the world can kill the virus within 48 hours.
Scientists from Monash University in Melbourne showed that a single dose of the drug, Ivermectin, could stop the SARS-CoV-2 virus growing in cell culture - effectively eradicating all genetic material of the virus within 48 hours.
The next steps are to determine the correct human dosage - ensuring the doses shown to effectively treat the virus in the test tube are safe levels for humans.
The use of Ivermectin to combat COVID-19 depends on pre-clinical testing and clinical trials, with funding urgently required to progress the work.
Ivermectin is an FDA-approved anti-parasitic drug that has also been shown to be effective in vitro against a broad range of viruses including HIV, Dengue, Influenza and Zika virus.
The findings of the study were published today in Antiviral Research.
A collaborative study led by Monash University's Biomedicine Discovery Institute (BDI) in Melbourne, Australia, with the Peter Doherty Institute of Infection and Immunity (Doherty Institute), has shown that an anti-parasitic drug already available around the world kills the virus within 48 hours.

The Monash Biomedicine Discovery Institute's Dr Kylie Wagstaff, who led the study, said the scientists showed that the drug, Ivermectin, stopped the SARS-CoV-2 virus growing in cell culture within 48 hours.

"We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours there was a really significant reduction in it," Dr Wagstaff said.

Ivermectin is an FDA-approved anti-parasitic drug that has also been shown to be effective in vitro against a broad range of viruses including HIV, Dengue, Influenza and Zika virus.

Dr Wagstaff cautioned that the tests conducted in the study were in vitro and that trials needed to be carried out in people.

"Ivermectin is very widely used and seen as a safe drug. We need to figure out now whether the dosage you can use it at in humans will be effective - that's the next step," Dr Wagstaff said.

"In times when we're having a global pandemic and there isn't an approved treatment, if we had a compound that was already available around the world then that might help people sooner. Realistically it's going to be a while before a vaccine is broadly available.

Although the mechanism by which Ivermectin works on the virus is not known, it is likely, based on its action in other viruses, that it works to stop the virus 'dampening down' the host cells' ability to clear it, Dr Wagstaff said.

Royal Melbourne Hospital's Dr Leon Caly, a Senior Medical Scientist at the Victorian Infectious Diseases Reference Laboratory (VIDRL) at the Doherty Institute where the experiments with live coronavirus were conducted, is the study's first author.

"As the virologist who was part of the team who were first to isolate and share SARS-COV2 outside of China in January 2020, I am excited about the prospect of Ivermectin being used as a potential drug against COVID-19," Dr Caly said.

Dr Wagstaff made a previous breakthrough finding on Ivermectin in 2012 when she identified the drug and its antiviral activity with Monash Biomedicine Discovery Institute's Professor David Jans, also an author on this paper. Professor Jans and his team have been researching Ivermectin for more than 10 years with different viruses.

Dr Wagstaff and Professor Jans started investigating whether it worked on the SARS-CoV-2 virus as soon as the pandemic was known to have started.

The use of Ivermectin to combat COVID-19 would depend on the results of further pre-clinical testing and ultimately clinical trials, with funding urgently required to keep progressing the work, Dr Wagstaff said.

###

Read the full paper in Antiviral Research titled: The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro: https://www.sciencedirect.com/science/article/pii/S0166354220302011



'This would be too simple...'

If Malaria medicine can work...

[helmsdale]

One day does not make a trend, but this is the first day since Italy delved head first into this mess that Serious and Critical numbers have declined. Yesterday they had 4068, today it is 3994. Current hospitalization occupancy has not started to decline yet. Yesterday 28741 in hospital, today 29,010. That's 24 days after they went full quarantine.